Impact of Tardive Dyskinesia on Quality of Life
January 20th 2025Panelists discuss how untreated tardive dyskinesia severely impacts patients' daily functioning and quality of life through physical limitations affecting basic tasks like eating and walking, social isolation due to visible symptoms, and heightened risks for older adults who face increased fall risks, difficulty maintaining independence, and complications from age-related comorbidities.
USP Calls for Pharmacists to Volunteer to Advance Global Public Health Standards
January 20th 2025Farah Towfic, PharmD, MBA, RPh, explains the importance of USP's expert volunteer recruitment, particularly among pharmacists, to help create public quality standards, promote health literacy, and support initiatives, with applications open until March 13, 2025, for the next strategic cycle beginning July 1, 2025.
US Pharmacopeia Provides Resources to Support Supply Chain Resilience Amid Drug Shortages
January 16th 2025Farah Towfic, PharmD, MBA, RPh, discusses how US Pharmacopeia helped to strengthen supply chain resilience in 2024 through data-driven insights, policy advocacy, and pharmacist engagement to address prolonged drug shortages, particularly for generic sterile injectables.
Additional Safety Considerations With PBC Treatments
January 15th 2025Panelists discuss how managing primary biliary cholangitis (PBC) in women of childbearing age requires careful consideration of pregnancy risk categories for different medications, with UDCA being the safest option during pregnancy, while second-line therapies require strict contraception and careful monitoring of hormone interactions to ensure optimal safety and efficacy.
Analyzing Hepatotoxicity as a Safety Concern With PBC Therapies
January 15th 2025Panelists discuss how hepatotoxicity risks vary among second-line primary biliary cholangitis (PBC) treatments, with seladelpar and elafibranor showing favorable hepatic safety profiles compared to obeticholic acid, though all require regular liver function monitoring and dose adjustments based on individual patient response and disease severity.
Safety Considerations When Initiating Treatment for PBC
January 8th 2025Panelists discuss how safety considerations for primary biliary cholangitis (PBC) treatment include monitoring liver function tests, managing pruritus and fatigue, assessing drug interactions, and evaluating individual patient factors like pregnancy status and comorbidities, which all influence the choice between ursodeoxycholic acid and second-line therapies.
Long-Term Considerations for PBC Treatment Options
January 8th 2025Panelists discuss how sustained treatment success in primary biliary cholangitis (PBC) requires regular monitoring of biochemical response markers, assessing patient adherence, managing potential adverse effects, and making timely adjustments to treatment strategies based on individual patient responses to seladelpar and elafibranor.
Examining Elafibranor as a Treatment Option for PBC
January 1st 2025Panelists discuss how elafibranor demonstrated significant efficacy in the ELATIVE trial, which strengthens confidence in its role as a long-term treatment option for patients with primary biliary cholangitis (PBC) who inadequately respond to ursodeoxycholic acid.
Improving Transitions of Care for Patients Receiving Bispecific Therapies and Final Recommendations
December 30th 2024Panelists discuss how key recommendations for optimizing bispecific therapy care focus on establishing robust communication protocols between academic and community centers while ensuring community centers develop comprehensive infrastructure including staff training, emergency protocols, and care coordination pathways.
Administering Bispecifics in the Community vs Academic Centers
December 30th 2024Panelists discuss understanding the comparative advantages, decision-making factors, infrastructure requirements, and partnership models for administering bispecific antibodies in community vs academic settings, with particular focus on patient care logistics and referral pathways.
Exploring Second-Line Treatments for PBC
December 25th 2024Panelists discuss how some patients with primary biliary cholangitis (PBC) have an inadequate response to ursodeoxycholic acid and require second-line treatments, with options including obeticholic acid, seladelpar, and elafibranor, which improve bile acid homeostasis and reduce inflammation.
Treatment Goals for Patients With PBC
December 25th 2024Panelists discuss how the main treatment goals for patients with primary biliary cholangitis (PBC) include improving liver biochemistry, preventing disease progression to cirrhosis, managing symptoms, and enhancing overall quality of life through regular monitoring and appropriate therapeutic interventions.