Lung Cancer

PD-L1 immune checkpoint inhibitors are now standard for early-stage non-metastatic non-small cell lung cancer (NSCLC), with neoadjuvant, adjuvant, and perioperative strategies improving survival and outcomes.

Tarlatamab was approved by the FDA in May 2024 for patients who progressed after platinum-based chemotherapy.

The Western diet was associated with increased risk of lung cancer.

Trastuzumab rezetecan is a novel antibody-drug conjugate.

Glecirasib is a potent oral inhibitor of KRASG12C.

The administration of immunotherapy in adjuvant, neoadjuvant, and perioperative settings offers distinct benefits and challenges in resectable cancers, with recent clinical trials highlighting its potential to improve long-term outcomes and the need for further research into biomarkers and combination strategies.

Priority review status will allow for expedited development of zongertinib, putting it on the path toward approval as the first in a new class of drugs for mutated NSCLC.

Second-line and later treatment options for small cell lung cancer are limited.

DLL3 is an emerging therapeutic target in small cell lung cancer and other neuroendocrine carcinomas, with 1 FDA-approved therapy and several others under investigation.

The cancer cells developed their own electrical network similar to neural behavior seen in the brain.

Up to 61% of all non-small cell lung cancer (NSCLC) cases harbor EGFR mutations.

The study results build on the “obesity paradox,” which suggests that patients with cancer and obesity have better outcomes.

As lung cancer cases rise, there is a significant need for therapeutic options that meet the challenges and needs of individual patients.

Preliminary phase 1 trial results demonstrate that patients with small cell lung cancer generated early clinical activity after being administered ZL-1310.

The FDA proposes to cap the nicotine level at 0.7 mg per gram of tobacco in cigarettes and certain other combusted tobacco products.

Radon is a tasteless, odorless radioactive gas associated with DNA damage and high genomic tumor instability.

Wildfire smoke carries toxic compounds that can trigger respiratory inflammation and cause cellular damage.

According to the investigators, BBO-8520 represents a first-in-class approach to treating patients with previously treated KRASG12C-mutated metastatic non-small cell lung cancer (NSCLC).

Datopotamab deruxtecan was also granted breakthrough therapy designation in December 2024.

In a phase 2 trial (NCT05400226), abenacianine helps surgeons visualize tumors in lung during surgery and is safe and well-tolerated in patients.

Sunvozertinib was originally approved in China, making it the world’s first and only oral treatment for these patients.

The model, Deep-IO, shows improved specificity and sensitivity compared with existing predictive biomarkers.

The approval offers patients with solid tumors an alternative to intravenous PD-1 inhibitor administration.

Bispecific antibodies amivantamab and tarlatamab hold promise for patients.

Pharmacists can help address nicotine addiction by recommending FDA-approved smoking cessation methods and educating on the risks associated with electronic cigarette use.

The indication is for patients with locally advanced or metastatic disease who have not previously received treatment with an ALK-inhibitor.

Abstract data presented in September demonstrate that the drug elicited strong antitumor activity in the second line in both platinum-sensitive and -resistant patients.

Zenocutuzumab-zbco is a bispecific antibody that targets and binds to HER2 and HER3.

The indication is for adults with limited-stage small cell lung cancer (LS-SCLC) whose disease has not progressed after platinum-based chemotherapy and radiation therapy.

Sacituzumab tirumotecan (sac-TMT; Kelun Pharmaceutical, Merck) is currently being studied to treat non-small cell lung cancer (NSCLC) in the TroFuse-004 and TroFuse-009 trials.