Colorectal Cancer

Commonly used medications may influence responses to checkpoint inhibitors among patients with cancer.

The FDA initially approved regorafenib for chemorefractory metastatic colorectal cancer and unresectable gastrointestinal stromal tumor in 2012.

Study finds that 16.9% of stomach cancers, 11.9% of endometrial cancers, 11.0% of kidney cancers, 9.3% of colon cancers, 8.1% of esophageal cancers, 6.5% of female breast cancers, and 3.9% of urinary bladder cancers were associated with a low level of exercise.

Chemotherapy for colorectal cancer include 5-fluorouracil (5-FU), capecitabine (Xeloda), irinotecan (Camptosar), oxaliplatin (Eloxatin), and trifluridine and tipiracil (Lonsurf).

The majority of treatment-related adverse events (TRAEs) were grade 1-2 in severity, and no patients experienced dose-limiting toxicities during the 28 days following initial treatment.

The combination of cetuximab and encorafenib resulted in a median overall survival of 8.4 months, compared to 5.4 months in the control arm among patients with colorectal cancer.

Umeā University in Sweden finds a connection between the two, due to the intestinal micobiome.

The continued approval for this indication may be subject upon verification and description of clinical benefit in a confirmatory trial.

Patients with microsatellite stable (MSS) colorectal cancer, which represents 95% of all metastatic colorectal cancer cases, are more responsive to checkpoint blockade immunotherapy if the patient’s tumors have not spread to the liver.

New research presented at the ESMO World Congress on Gastrointestinal Cancer suggests the use of antibiotics may increase the risk of colon cancer, especially in individuals under age 50 years.

The current study analyzed human tumor samples from 6 cancer types: liver, melanoma, colorectal, non-small lung, head and neck, and breast cancer.

Further, the ISCs reside in a series of regularly folded valleys of the gut, which the researchers call crypts.

Incidence rates of early-onset colorectal cancer in the United States have increased from 8.6 to 13.1 per 100,000 between 1992 and 2013, with most of this increase attributable to early-onset cancers of the rectum.

The percentage dropped to only about 25% among people at a low genetic risk for the disease.

The incidence of colorectal cancer in adults between the ages of 40 and 49 years has increased by nearly 15% since 2000.

The implementation of multi-gene panel testing may be a necessary part of the standard of care for all colorectal cancer patients.

In June 2020, the FDA granted a fast track designation to fruquintinib for patients with mCRC previously treated with other therapies.

Individuals with an average risk of colorectal cancer said they would prefer a stool-based screening test for colorectal cancer over colonoscopy.

The study also analyzed the relationship between ultra-processed food and drink products with 2 other cancer types.

A new study published in The American Journal of Clinical Nutrition found that for colorectal cancer survivors, maintaining a stable body weight may hide a loss of muscle and the development of fatty deposits in their muscles, which resulted in a 40% higher risk of premature death.

The findings suggest pre-diagnosis aspirin use might help reduce CRC mortality in the overall population by limiting metastatic spread of colorectal tumors before diagnosis.

If approved, the biosimilar will be indicated for use in metastatic colorectal cancer, nonsquamous non–small cell lung cancer, recurrent glioblastoma, metastatic renal cell carcinoma, and metastatic cervical cancer.

Pharmacists should communicate the universal message that colorectal cancer screenings save lives.

A new combination therapy cleanses the colon before this important procedure that screens for colorectal cancer, the third-leading cause of cancer-related deaths in the United States.

The United States Preventive Services Task Force updates recommends that colorectal cancer screening begin 5 years earlier, at age 45 instead of age 50.

The COVID-19 pandemic has caused many routine colorectal cancer screenings to be delayed.

A patient has Lynch syndrome, a hereditary condition that puts young people at high risk for colon cancer.

By using a non-invasive screening model, care providers can help catch and treat more cases of colorectal cancer, a new study suggests.

Leung added that this is the first study to show the potential beneficial effects of ACE inhibitors and ARBs on colorectal cancer development, based on a large group of patients who were colorectal cancer-free at the beginning of the study.

According to a press release, this is the first single-agent, anti-PD-1 therapy approved in the first-line environment for this patient population.