C. difficile

Andrew Skinner, MD, reviews challenges in managing CDI, as well as the treatment guidelines from IDSA, SHEA, and ACG.

Patients with C. difficile who received clonal bacteria populations via biotherapeutic injection were able to repopulate their microbiota with commensal bacteria.

Joseph Reilly, BS, PharmD, BCGP; Candace Cotto, RN; and Andrew Skinner, MD, review C. difficile infection (CDI), its risk factors, symptoms, and quality of life for the patient.

Experts provide an overview of the gut microbiome and its importance to nutrition and overall health.

The infection causes diarrhea and inflammation of the colon, and it can be difficult to get rid of it.

Cephalosporin treatment is a risk factor of Clostridioides difficile infection.

Through 8 weeks after treatment, C. difficile recurrence in SER-109-treated participants was lower compared to placebo-treated participants.

Fecal microbiota transplantation may result in a slight reduction in serious adverse events, but the confidence intervals around the summary estimate were wide in immunocompetent adults with recurrent C. difficile infection.

Investigators use a large PCR-only data set to confirm that PCR CT can predict recurrence-free survival, using Cox proportional hazards regression.

The 2 most hypervirulent strains of Clostridioides difficile are associated with the consumption of pork and shellfish.

These are used to help reduce inappropriate testing, where an expert consults with medical directors of infection prevention and control for a test-order override.

Not only are pharmacists easily accessible to the public, they are also highly visible as a source for travel immunization services.

Similarities between the symptoms of Clostridioides difficile infection and Crohn disease may cause confusion for health care providers.

The main cause of C. diff infection remains antibiotic use and overuse.

Spherix Global Insights estimates that SER-109 (Seres Therapeutics; Aimmune) will be able to challenge fecal microbiota, live-jslm in C. difficile treatment.

Clostridioides difficile infection can have a significant impact on feelings of depression and anxiety, while worsening quality of life.

Including probiotics and antibiotics, such as fidaxomicin and vancomycin, could help prevent CDI, but more research is needed to evaluate them, investigators say.

Although antibiotics are an effective treatment option, evidence indicates that fecal microbiota transplant holds promise in treating refractory or recurrent C difficile infections.

Extended infusion piperacillin/tazobactam was associated with lower odds of 14-day mortality compared to standard infusion piperacillin/tazobactam.

Although investigative team is predominantly investigating Priscilicidin for topical applications, they are not ruling out potential oral applications.

New guidance provides recommendations on infection prevention strategies, performance measures, and how to implement these approaches.

Study findings mark the first evidence of improved health-related quality of life scores following treatment with an investigational microbiome agent in patients with recurrent Clostridioides difficile.

Study shows a statistically significant improvement in inflammatory syndrome after a fecal microbiota transplant in patients coinfected with COVID-19 and clostridioides difficile.

Investigators emphasize the importance of a timely HLH diagnosis and prompt initiation of treatment, as well as close outpatient follow-up to increase patient survival.

An organ transplant is a known risk factor for C. difficile infection, however, data are lacking on how the infection affects those who underwent an intestinal transplant.

Molecular methods such as polymerase chain reaction show promise in monitoring the patient environment in hospitals and could help to provide reassurance prior to admission.

Clostridium difficile is a gram-positive, spore-forming, bacterium that is mainly caused by recent hospitalizations, advanced age, or antibiotic treatments.

Patients with cystic fibrosis are typically administered antibiotics throughout their lives, which can increase the risk for C difficile infections.

Live-jslm (Rebyota; Ferring Pharmaceuticals) is indicated for the prevention of recurring Clostridioides difficile infection among patients 18 years of age and older after an antibiotic treatment.

The relative abundance of gram-negative Bacteroidetes to other phyla, such as gram-positive Firmicutes, is essential to maintain biodiversity and human gut health.