Lauren Ledbetter, PharmD, BCOP

A panelist discusses how evidence-based protocols for managing infusion-related reactions have reduced hesitancy among health care providers to use agents like amivantamab, empowered the entire care team with knowledge, and balanced the benefits and challenges of oral vs intravenous (IV) chemotherapy administration in relation to patient autonomy, adherence, and quality of life.

A panelist discusses how clinical trials and institutional guidelines have improved the management of infusion-related reactions (IRRs) through standardized premedication protocols, including the SKIPPirr trial, which demonstrated that home dexamethasone use prior to amivantamab infusions can significantly reduce reaction rates from 67% to 22.5%.

A panelist discusses how to minimize EGFR tyrosine kinase inhibitor (TKI) adverse effects through preventive measures such as maintaining good skin regimens with moisturizers and SPF 30+ sunscreen, prescribing topical steroids and antibiotics for skin rash, and managing diarrhea with hydration, diet modifications, and loperamide.

A panelist discusses how EGFR tyrosine kinase inhibitors (TKIs) commonly cause dermatologic toxicities (including acneiform rash, dry skin, photosensitivity, and paronychia) and diarrhea, which can significantly impact patients’ quality of life by causing physical discomfort, affecting appearance, and limiting daily activities.