Pharmacist Impact in CML: Advancing Access and Frontline Treatment Decisions
Carmen Janes, PharmD, BCOP, discusses how National Comprehensive Cancer Network guidelines inform first-line chronic myeloid leukemia (CML) treatment selection among tyrosine kinase inhibitors such as imatinib, nilotinib, and asciminib, emphasizing the importance of early molecular milestone achievement, proactive toxicity management, and the expanding role of pharmacists in optimizing patient adherence and quality of life through remote monitoring and medication access support.
EP. 1: NCCN Guidelines and Early Response Monitoring in Chronic Myeloid Leukemia
June 27th 2025An expert discusses how National Comprehensive Cancer Network (NCCN) guidelines recommend first-line chronic myeloid leukemia (CML) treatments including imatinib, nilotinib, and newer agents, emphasizing the importance of close monitoring through weekly laboratory tests and quantitative polymerase chain reaction (PCR) to track BCR::ABL1 transcript levels and ensure patients meet critical milestones at 3, 6, and 12 months.
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EP. 2: Shifting Therapeutic Urgency and TKI Strategy
June 27th 2025An expert discusses how different tyrosine kinase inhibitor (TKI) mechanisms of action, including asciminib’s allosteric binding vs traditional ATP-competitive inhibitors, influence treatment selection based on off-target effects and adverse effect profiles, with patients with advanced-phase chronic myeloid leukemia (CML) requiring second-generation or higher TKIs for faster response rates.
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